Antidepressants blocked by other drugs?

I recently read an interesting article in Arthritis Today. It spoke of the interactions among pharmaceutical antidepressants and the use of NSAIDs to control inflammation and pain. So many use NSAIDs to help relieve other health challenges and unknowingly change the outcome of their prescription drugs.
I ask why do they not move to a natural anti-inflammatory that would help resolve the inflammation and quite possibly increase the result they receive from their medication thereby reducing the amount of pharmaceuticals needed for the depression.
Taking a more proactive approach to health and asking the question...does this course of action move me in the direction of long term health. If not, then being open to other options and educating oneself should be the next logical step.
Too often we are ready to jump right to the quick fix pill rather than look deeper at treating the underlying issues at hand.