Accelerated antioxidant bioavailability of OPC-3 bioflavonoids administered as isotonic solution.

Cesarone MR, Grossi MG, Di Renzo A, Errichi S, Schönlau F, Wilmer JL, Lange M, Blumenfeld J.

Department of Biomedical Science, G D'Annunzio University Chieti, Pescara, Italy.
Abstract
Phytother Res. 2009 Jun;23(6):775-7.

Accelerated antioxidant bioavailability of OPC-3 bioflavonoids administered as isotonic solution.


The degree of absorption of bioflavonoids, a diverse and complex group of plant derived phytonutrients, has been a frequent debate among scientists. Monomeric flavonoid species are known to be absorbed within 2 h. The kinetics of plasma reactive oxygen species, a reflection of bioactivity, of a commercial blend of flavonoids, OPC-3 was investigated. OPC-3 was selected to compare absorption of an isotonic flavonoid solution vs tablet form with the equivalent amount of fluid. In the case of isotonic OPC-3 the reactive oxygen species of the subject's plasma decreased significantly (p < 0.05), six times greater than OPC-3 tablets by 10 min post-consumption. After 20 min the isotonic formulation was approximately four times more bioavailable and after 40 min twice as bioavailable as the tablet, respectively. At time points 1 h and later, both isotonic and tablet formulations lowered oxidative stress, although the isotonic formulation values remained significantly better throughout the investigation period of 4 h. These findings point to a dramatically accelerated bioavailability of flavonoids delivered in an isotonic formulation.
(c) 2009 John Wiley & Sons, Ltd.

PMID: 19172583 [PubMed - indexed for MEDLINE]

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